National Research Council of Italy

Institute of Biosciences and BioResources

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IBBR Project #112

NEMATIC - Materiali Nanoporosi: Lavagne Autoassemblanti per lo Studio della Struttura e delle Interazioni del DNA
Project ID 112
ID n/a
Acronym -
Project acronym and title NEMATIC - Materiali Nanoporosi: Lavagne Autoassemblanti per lo Studio della Struttura e delle Interazioni del DNA
Contract -
Description NEMATIC is a highly multidisciplinarity project integrating biochemistry and molecular biology, biophysics, chemistry and molecular dynamics, with the aim to develop nanopore-based microarray devices for the study of DNA structure, topology and interaction with proteins. Protein-induced DNA structure and topology modifications are crucial in all DNA activities.

Self-assembled nano- and mesoporous material will be fabricated and used to set up nanopores to study, through the analysis of the nucleic acid electrically driven nanopore translocation, DNA structural modifications induced by selected thermophilic and mesophilic DNA-acting proteins. Nanopore-based innovative microsystems will enhance laboratory practice by permitting spatial and temporal analytical resolution of DNA structure modifications and DNA-protein interactions down to the single-molecule level.

Other partners:
- Dipartimento di Fisica Università di Trento
- Istituto di Chimica del Riconoscimento Molecolare (ICRM), CNR, Milano
- Istituto dei Processi Chimico-fisici (IPCF), CNR, Roma
Funding body MIUR-FIRB
UOS Napoli
Role Research Unit
Signatory -
Contact Person Valenti Anna
Starting of activities 2013
Ending of activities 2016
Extension -
Amount (euro) 204000.00
Technological Area -
Technological Field -
Select Projects
Istituto di Bioscienze e Biorisorse (IBBR/CNR)
Via G. Amendola 165/A, I-70126 Bari (Italy)
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